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Rev Clin Periodoncia Implantol Rehabil Oral. 2008;1:101-103

Empleo de Agentes Farmacológicos en Dentífricos como Moduladores de la Infección e Inflamación Periodontal

Use of Pharmacological Agents in Dentifrices for the Prevention of Periodontal Disease

Smith P1, Arancibia R1, Martínez J2.

1Laboratorio de Fisiología Periodontal. Carrera de Odontología. Centro de Investigaciones Médicas (CIM). Facultad de Medicina Pontificia Universidad Católica de Chile. Chile.
2Laboratorio de Biología Celular. INTA, Universidad de Chile. Chile.


La enfermedad periodontal causa importantes efectos deletéreos en la dentición humana, provocando la degradación del tejido de soporte periodontal y eventualmente la pérdida de la dentición. Por otro lado, existen evidencias que sugieren que esta infección puede comprometer la salud general del paciente. La prevención de esta enfermedad puede tener entonces importantes repercusiones en la salud pública y las herramientas para prevenir o controlar esta patología ameritan la implementación de medidas basadas en el autocuidado y la prevención por parte del propio paciente. Es en este sentido que el desarrollo de productos que faciliten el control de placa bacteriana y reduzcan los niveles de inflamación en el tejido periodontal podría tener efectos beneficiosos en la salud oral de nuestra comunidad. En la presente revisión se analiza el papel de agentes farmacológicos utilizados en dentífricos que pueden tener un efecto positivo en el control de la gingivitis y enfermedad periodontal.

Palabras clave: Prevención, dentífrico, triclosán, enfermedad periodontal.


Periodontal disease may cause significant deleterious effects in human dentition including the destruction of the periodontal attachment system and eventually tooth loss. There is also a growing body of scientific evidence that suggests a role for periodontal infections in the deterioration of the systemic health. Therefore, prevention of periodontal disease may have significant effects in public health. Strategies to prevent this disease should consider the role of oral health care products that may be utilized by patients at the individual level. In this sense, the development of new pharmacological products focused on the modulation of periodontal infection and inflammation should be envisaged as an interesting alternative for the prevention of periodontal disease. The present review analyses the role of pharmacological agents, used in dentifrices, that may have a positive effect in the control of gingivitis and periodontal disease.

Key words: Prevention, dentifrice, triclosan, periodontal disease.

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Trabajo recibido el 10/10/2008.
Aprobado para su publicación el 04/11/2008.

Patricio Smith.
Marcoleta 391. Santiago, Chile.
Laboratorio de Fisiología Periodontal Centro de Investigaciones Médicas,
Carrera de Odontología. Facultad de Medicina Pontificia Universidad
Católica de Chile.

Copyright © 2008.
Sociedad de Periodoncia de Chile, Sociedad de Implantología Oral de Chile y Sociedad de Prótesis y Rehabilitación Oral de Chile.